PreSENTIA – Cancer Screening Tests

Description

WHAT IS PreSENTIA?

PreSENTIA is an extensive portfolio of 19 hereditary cancer panels. Each panel focuses on a particular set of genes that determine your chances of developing cancer in the future. The genetic changes (mutations) in the genes that cause cancer can be inherited from parents to their children.

WHAT ARE ‘HEREDITARY CANCER SYNDROMES’?

Hereditary cancer syndromes are also known as cancer predisposing syndromes, as people with these syndromes have an elevated risk of developing specific cancers in the future. These conditions occur when genes with critical roles in keeping our body healthy are mutated, causing a variety of symptoms and potentially affecting the quality of life. They can be inherited from one generation to the other.

HEREDITARY CANCER SYNDROMES CHARACTERISTICS

• Multiple cancer types
• Repeated cancers
• Young age of cancer onset If you have cancer in your family history and want to know about your own risk, PreSENTIA can help.

By identifying the mutated genes that could cause hereditary cancer syndromes, PreSENTIA can provide information that could help in clinical management. If you have been diagnosed with cancer and have any of the above characteristics, you might also have a hereditary cancer syndrome. Identifying this can help reveal how and why your cancer was caused.

WHAT IS CANCER?

Cancer is the rapid and uncontrollable growth of abnormal cells. It is the second leading cause of death, responsible for 1 out of 6 deaths globally. World Health Organization (WHO) has recommended that cancer mortality can be significantly reduced by early detection and proper clinical management of cancers.

HOW DOES CANCER DEVELOP?

Cancer develops after certain genes that are responsible for keeping our body healthy are changed (mutated). A cancer can be:

• Sporadic: Mutations in the genes causing cancer accumulate over time due to risk factors like chemical and environmental factors. These mutations cannot be inherited.
• Hereditary: These mutations exist from birth. They run in families and can be passed down from parents to their children. They do not always develop into cancer – but they raise someone’s chances of developing cancer in the future. Inherited genetic mutations make up for 5-10% of all cancers.

If you or a family member were diagnosed with hereditary cancer, or a genetic change that is linked to cancer, there’s a high chance other members of your family carry the mutation as well. Each individual could be affected by cancer at different age, with wide range in severity, and by different cancer types – or not develop cancer at all.

According to genetic testing guidelines*, the risk of developing hereditary cancer is high if you have:

• Family members with cancer in the same side of the family
• Family members with early cancer onset
• Family members with rare cancer types
• A family member with multiple cancersA family member that has been diagnosed with a genetic mutation that has cancer susceptibility

* Data adapted from: American Cancer Society, National Cancer Institute, American
Society of Clinical Oncology and American College of Obstetricians and Gynecologists

HOW DOES PreSENTIA HELP ME?

PreSENTIA panels test for numerous genetic changes that are responsible for causing hereditary cancers. If you want to know more about your cancer risks, or if you have already been diagnosed with cancer and you want to know whether your cancer is hereditary, PreSENTIA can help.

KNOW YOUR GENES, KNOW YOUR CHOICES:

PreSENTIA can potentially identify the genetic changes that could cause cancer. This has many benefits on planning, prognosis and directing better treatment decisions:

• Targeted cancer monitoring – recommended screening tests at key time intervals to detect cancer early, when treatment is more beneficial
• Prevention of cancer by prophylactic measures
• Actionable information for family members that might carry the same genetic mutation
• Improved classification of the disease for better clinical management
• Drug therapy (chemoprevention), where applicable

WHY CHOOSE PreSENTIA?

• Assesses clinically important mutations
• Choice of multiple panels
• Reliable technology
• Short turn-around time
• Safe and easy to perform
• Pain free sample collection via a Buccal Cheek Swab – can be carried out in the comfort of your own home
• Results available within 14 -21 working days of sample arriving in laboratory

We always recommend that test results are discussed with your Healthcare Professional

Choice of tests:

PRESENTIA HEREDITARY BREAST/GYNECOLOGICAL CANCER PANEL (26 Genes) – £395

PRESENTIA HEREDITARY BREAST/GYNECOLOGICAL GUIDELINES BASED (19 Genes) – £395

PRESENTIA HEREDITARY BREAST CANCER – HIGH RISK (7 genes) – £355

PRESENTIA HEREDITARY BRCA1/BRCA2 CANCEL PANEL (2 Genes) – £335

PRESENTIA HEREDITARY COLORECTAL CANCEL PANEL (17 Genes) – £395

PRESENTIA HEREDITARY COLORECTAL CANCER PANEL – HIGH RISK (10 Genes) – £355

PRESENTIA HEREDITARY COLORECTAL NON POLYPOSIS CANCEL PANEL (5 Genes) – £335

PRESENTIA HEREDITARY POLYPOSIS CANCER PANEL (7 Genes) – £335

PRESENTIA HEREDITARY MYELODYSPLASTIC SYNDROME / LEUKEMIA CANCER PANEL (24 Genes) – £425

PRESENTIA HEREDITARY GASTRIC CANCER PANEL (14 Genes) – £395

PRESENTIA HEREDITARY PROSTRATE CANCER PANEL (15 Genes) – £395

PRESENTIA HEREDITARY PANCREATIC CANCER PANEL (17 Genes) – £395

PRESENTIA HEREDITARY RENAL CANCER PANEL (13 Genes) – £395

PRESENTIA HEREDITARY SKIN (XERODERMA – PIGMENTOSUM CANCER PANEL (9 Genes) – £395

PRESENTIA HEREDITARY FAMILIAL MELANOMA CANCER PANEL (7Genes) – £395

PRESENTIA HEREDITARY PARAGANGLIOMA/PHEOCHROMOCYTOMA CANCER PANEL (6 Genes) – £395

PRESENTIA HEREDITARY PARATHYROID CANCER PANEL (1 Gene) – £355

PRESENTIA HEREDITARY THYROID CANCER PANEL (1 Gene) – £355

PRESENTIA HEREDITARY PAN CANCER PANEL (62 Genes) – £999

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