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Price range: £355.00 through £1,975.00
PrenatalSafe NIPT is a range of prenatal screening tests available from 10 weeks of pregnancy. By analysing small pieces of placental DNA in a maternal blood sample, it estimates whether selected chromosome or genetic conditions are more or less likely.
With nine options, PrenatalSafe offers the widest choice within the My DNA Lab NIPT range. You can begin with focused screening for the three most common trisomies or choose broader chromosome, selected gene and parental carrier screening. This flexibility helps you select the scope that best matches the information you want, while the report can support an informed conversation with your midwife, GP or obstetric team.
A qualified healthcare professional must collect every required sample, as PrenatalSafe accepts blood samples only across the range. You can arrange collection locally or use My DNA Lab’s mobile phlebotomy service within mainland UK. Complete and Complete Plus require two maternal Streck tubes and one paternal EDTA blood sample. Full Risk requires two maternal Streck tubes, one maternal EDTA blood sample and one paternal EDTA blood sample. Follow the blood-sample instructions for your selected option carefully.
During pregnancy, small pieces of DNA from the placenta circulate in the pregnant woman’s blood. This is called cell-free DNA. PrenatalSafe analyses this DNA and reports whether the conditions included in your chosen option are more or less likely.
The range begins with trisomy 21 (Down’s syndrome), trisomy 18 (Edwards’ syndrome) and trisomy 13 (Patau’s syndrome). From there, wider options can assess more chromosomes, selected small missing or extra chromosome sections, and selected conditions caused mainly by one gene. Full Risk goes further by adding carrier screening for both biological parents across 30 inherited conditions.
Because the scope changes substantially between the nine options, compare the complete range in the PrenatalSafe brochure under ‘Test provider and further information’ further down this page. Whichever option you choose, PrenatalSafe remains a screening test: it does not assess every condition or confirm a diagnosis.
PrenatalSafe may suit you if you want access to prenatal screening from 10 weeks with a choice of focused or broader options. Some options may also be available for twin, IVF or donor pregnancies, although eligibility and reporting limits differ across the range.
If you know that you are expecting twins or triplets, the pregnancy has involved a vanishing twin, or donor eggs or sperm, IVF or a surrogate are involved, contact My DNA Lab before purchasing. We can confirm the current eligibility and exact sample requirements before you select an option.
Important: PrenatalSafe cannot report fetal sex in a dichorionic twin pregnancy, where the twins have separate placentas. This applies regardless of the option you choose.
If an ultrasound scan or family history has already raised a concern about a particular condition, a wide screening panel may not provide the most direct answer. A targeted clinical test may be more suitable for that specific question.
The prices above apply when blood collection is arranged through your own qualified healthcare professional. My DNA Lab’s mobile phlebotomy service within mainland UK adds £60 when blood is collected from one person or £120 when blood is required from both biological parents. Complete, Complete Plus and Full Risk each require a paternal blood sample collected by a qualified healthcare professional.
Your report gives a lower-chance or higher-chance result for the conditions included in your selected option. A lower-chance result makes those conditions less likely but cannot rule them out, while a higher-chance result does not confirm that the baby has a condition. We always recommend that you discuss your results with your healthcare professional and share a higher-chance result promptly with your midwife or obstetric team.
For a dichorionic twin pregnancy, fetal-sex information will not be included in the PrenatalSafe report, even when the selected option would normally provide it.
Free genetic counselling is available both before and after this test. Pre-test counselling can help you understand the differences between the options, while post-test counselling can help explain the report. To use either service, contact My DNA Lab and we will put you in touch with a representative from the testing provider. Your maternity team may also discuss diagnostic testing such as CVS or amniocentesis.
For Full Risk, the parental carrier screen does not test whether the baby has a recessive condition. Instead, it checks whether both biological parents carry selected gene changes that could increase the chance of passing on an included condition. A genetics professional can explain whether the finding suggests that further testing may be helpful.
Begin by deciding what you want the test to help you understand. PrenatalSafe 3 and 5 focus on common chromosome conditions, while the middle options expand chromosome and microdeletion screening. Complete, Complete Plus and Full Risk add selected gene-related information, with Full Risk also screening both biological parents for carrier status.
Although broader screening can provide more information, it is not automatically more useful. Wider options may identify findings that need further tests or are harder to explain. If a condition is already known in either biological family, a focused clinical test may be more suitable than the widest PrenatalSafe option. If you use the free pre-test counselling service, you can decide whether to discuss an existing family report during that session.
Whatever option you choose, continue all routine antenatal screening, scans and appointments offered by your maternity team.
